Abstract
Background: Progression of liver cirrhosis inevitably brings to the last chance of patient in life – liver transplantation. Unfortunately lack of liver donors is the cause for many such patients’ death.Alternative of liver transplantation could be transplantation of fetal liver progenitor cells (FLPC), which is successfully tested in Ukraine and in India it is in the stage of clinical trials. Objectives: Analysis ofbiosafety and effectivenessof fetal progenitor cells transplantation in liver cirrhosis. Methods: Transplantation of FLPCwas performed in 67 patients with liver cirrhosis. Level of change in cirrhotic damage of the liver was evaluated in dynamics by the data of biopsies, fibroscan, and likewise by the results of CT, USG, MRT. Besides, biochemical parameters were analyzed whichcharacterizescholestasis, cytolysis and liver failure syndromes. Results: Transplantation of FLPC showed effectiveness in 79% cases that is characterized by significant decrease in the parameters of density of liver (“E” reduced within one year from 71.5 to 7.6 Kpa), disappearance of portal hypertension and ascites, normalization of biochemical markers of liver damage. Conclusion: The most effective transplantation of FLPC showed in alcoholic liver cirrhosis, ineffective – in liver cirrhosis caused by hepatitis C virus, and likewise in patients with terminal stage disease. Mechanism of therapeutic action of FLPC related with direct replacement effect, stimulation to division of hostpatients hepatocytes and eliminates the autoimmune component of the disease. Sharp increase of tissue collagenolytic activity describes the regression of liver cirrhotic changes. Biography
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