Abstract
Laser speckle rheology is a powerful method to measure viscoelasticity of biological fluids. To date, the in vivo assessment of viscoelastic properties of biofluids has been limited by several reasons such as combined speckle fluctuation and insufficient detection depth. In order to avoid these shortcomings, in particular, the problems associated with detection depth during in vivo viscoelastic testing of biological fluids, the transmission method has been adapted in this work. According to the experimental results, the modified laser speckle rheology technique has enabled one to increase a speckle fluctuation range by nine times at keeping the same thickness of the biomimetic materials, which is of great significance for further in-vivo research.
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