Abstract
A model for the translation phenomenon is developed which allows computer simulations of control of protein synthesis at the translational level. The main parameters governing the model are: the rate of initiation, the rate of progression of the ribosomes along the mRNA, the rate of release of ribosomes from the mRNA, the amount of ribosomal subunits and the amount of mRNA in the system. Simulations are performed which evidence the influence of these parameters on experimentally available data such as: polyribosome profiles, rate of protein synthesis, mean transit time of ribosomes and distribution of ribosomes along the mRNA. The aim of this work is to lead to easier interpretation of experimental works dealing with translational control of protein synthesis.
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