Abstract
A stem-cell-based therapy could be the ultimate strategy for the regeneration of degenerated nervous tissues. While neural progenitor cells are limited, the generation of functional nervous tissue cells from non-neural somatic cells (for example, dental stem cells) is highly desired. The recent publication in Stem Cell Research and Therapy by Huang and colleagues is an interesting contribution to this topic. The present commentary puts this paper in context with contemporary reports about (transgene-free) induced pluripotent stem cells and neurogenic differentiation.
Highlights
A stem-cell-based therapy could be the ultimate strategy for the regeneration of degenerated nervous tissues
An appropriate strategy to improve the proliferation and the differentiation potential of somatic cells is the establishment of induced pluripotent stem cell (iPSC) with similar functional and molecular phenotypic characteristics to embryonic stem cells (ESCs) [5]
In the present study Huang and coworkers speculated that a permanent integration of viral vectors in iPSCs with a constitutive transgene expression may contribute to the unfavorable features of dental iPSCs [1]
Summary
A stem-cell-based therapy could be the ultimate strategy for the regeneration of degenerated nervous tissues. A recent study by George Huang and colleagues published in Stem Cell Research and Therapy used stem cells from the dental apical papilla (SCAP) [1]. SCAP, like other types of dental stem cells, are a favorable cell source for therapies of degenerated nervous tissues.
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