Abstract
Objective: To study the influence of transforming growth factor - β1(TGF-β1) on the left ventricle (LV) remodeling in patients with essential hypertension (EH) and type 2 diabetes mellitus (DM). Design and Methods: The 42 patients with EH and type 2 DM were examined. 20 healthy persons were included to control group. Structural and functional heart values were obtained by echocardiography in B- and M- regimen with a standard method using LOGIQ-5 device. Concentration of growth factor was determined by immunity enzyme assay. For TGF-β1 determination was used reagents of «DRG Instruments» (Germany) production Results: TGF-β1 blood level in hypertrophic types of LV remodeling was significally higher compared with healthy persons (6,8 ± 1,14) ng/ml. No differences in blood TGF-β1 concentrations were revealed between the patients with concentric and eccentric types of left ventricle hypertrophy (LVH) correspopondingly ((17,2 ± 1,21) ng/ml and (15,8 ± 1,16) ng/ml; p > 0,05). The data obtained show that the investigated growth factor was involved in the process of pathological heart remodeling in patients with EH and type 2 DM. Concentric type of LVH is characterized by activation of TGF-β1 synthesis while eccentric type of LVH is characterized by elevated synthesis of TGF-β1. Conclusions: The role TGF-β1 in the development of LVH in patients with EH and type 2 DM was estabilished in this work. The pathogenetic role of TGF-β1 activation in the development of LVH in patients with essential hypertension and type 2 diabetes mellitus.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
