Abstract
Transdermal drug delivery offers numerous advantages in comparison to conventional delivery methods. However, the stratum corneum as the first layer has been the limiting barrier to some drugs so that no compilation permeable is applied to the skin. Permeation enhancers are now a solution for limitation in transdermal delivery systems, which are available as chemical or physically permeation enhancers . But sometimes these systems still have skin safety issues. V esicle is a system that delivers
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