Angewandte Chemie (International ed. in English) | VOL. 61

Transesterification of Non-Activated Esters Promoted by Small Molecules Mimicking the Active Site of Hydrolases.

Publication Date Aug 26, 2022


The synthesis of small molecules able to mimic the active site of hydrolytic enzymes has been largely pursued in recent decades. The high reaction rates and specificity shown by natural hydrolases present an attractive target, and yet the preparation of suitable small-molecule mimics remains challenging, requiring activated substrates to achieve productive outcomes. Here we present small synthetic artificial enzymes which mimic the catalytic site and the oxyanion hole of chymotrypsin and N-terminal hydrolases and are able to perform, for the first time, the transesterification of a non-activated ester such as ethyl acetate with methanol under mild and neutral reaction conditions.


Neutral Reaction Conditions N-terminal Hydrolases Small-molecule Mimics High Reaction Rates Ethyl Acetate Active Site Of Enzymes Small Molecules Mild Reaction Conditions Site Of Enzymes Synthetic Enzymes

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No potential conflict of interest was reported by the authors. The conception and design of the study, acquisition of data, analysis and interpretatio...

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