Abstract
Pulmonary drug delivery systems have long been explored for delivering drugs possessing different characterstics, for example, drugs which cannot be given by conventional routes due to their stability issues, or drugs that target CNS but do not cross the blood–brain barrier. There are certain advantages which make it a suitable route compared with other routes of drug delivery. Lung histology, various barriers in pulmonary drug delivery, adaptations to overcome those barriers, and various mechanisms of drug absorption and deposition are explained in this chapter. It also contains examples of certain drug molecules which are presently delivered through this route, classified on the basis of their molecular size. Transepithelial drug delivery through the pulmonary route has recently been explored for novel applications. This chapter aims to present a detailed study of various aspects of pulmonary drug delivery. A brief explanation of stratergies of improving drug delivery through this route is also explained in this chapter.
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