Abstract
This chapter summarizes the progress made in elucidating the contribution of pHin to the series of events which lead mammalian cells to proliferate in response to growth factors. In particular, the characterization of mutants which have lost the Na+:H+ exchange function proved of great value to demonstrate that an efficient regulation of pHin is essential for both normal and malignant cells in order to maintain an active rate of division under diverse environmental situations. An outline of some of the reactions which have been shown to occur during the early phase of the response of Chinese hamster lung fibroblasts (CCL39) to growth-promoting substances is represented. To substantiate the notion that the lack of a functional Na:H antiport activity is not detrimental to the acquisition of transformed characteristics per se, the activated human Harvey-rax oncogene was transfected into CCL39 and PS120 cells.
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