Abstract
AbstractIn the second report of this series of investigations, series of alkanols, alkanoic acids and propyl alkanoates were evaluated for their potential as skin permeation enhancers for testosterone and estradiol delivered from a multilaminate-type transdermal drug delivery (m-TDD) system. Results indicated that permeation rates vary with the length of alkyl chain and the maximum enhancement effect is attained with alkanol having n=6–8 (n is the number of methylene groups), alkanoic acid having n=8–10, and propyl alkanoate having n=10–12. The enhancing effect of series of sorbitan esters and polysorbates on the skin permeation of testosterone was also studied; and the results indicated that sorbitan esters are effective skin permeation enhancer, while polysorbates are not. The effect of enhancer loading on the skin permeation rates of testosterone and estradiol, the barrier property of permselective membrane, the dosage rate ratio of testosterone/estradiol was extensively studied; and the effect of vari...
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