Abstract
Ascorbic Acid 2-Glucoside (AA2G), l-ascorbic acid derivatives, is provided whitening, anti-oxidation effect and more stable in physicochemical properties. AA2G used in the cosmetic industrial area, however, it hydrophilic character caused lower ability across stratum corneum to the skin, the whitening effect was limited. A microemulsions is the best choice in the study due to the scale up easily in the cosmetic industrial. We aim to optimized microemulsion formulation which easily preparation and stabilized in the cosmetic industrial and enhance the penetration ability into skin simultaneous remain lightening effect. AA2G microemulsion was prepared archive approximately 150 nm. The results showed that the AA2G microemulsion has powerful permeation ability and high skin deposition when compared with the AA2G aqueous control solution and the commercial emulsion product (p<0.05). In human study demonstrated that AA2G microemulsion group could archived lightening (c*) and colorful (e*) by colormery evaluation. The results support that AA2G microemulsion as a potential carrier application in the cosmetic industrial.
Highlights
Publication History: Ascorbic Acid 2-Glucoside (AA2G), l-ascorbic acid derivatives, is provided whitening, anti-oxidation effect and more stable in physicochemical properties
AA2GTM was originally developed as a quasi-drug in Japan to lighten the overall tone of the skin and reduce the pigmentation in age spots and freckles
The use of AA2G in cosmetic products has been limited owing to its labile oxidative properties, which can be accelerated in the presence of oxygen, water, light, heat and metals [13,14]
Summary
Publication History: Ascorbic Acid 2-Glucoside (AA2G), l-ascorbic acid derivatives, is provided whitening, anti-oxidation effect and more stable in physicochemical properties. AA2G used in the cosmetic industrial area, it hydrophilic character caused lower ability across stratum corneum to the skin, the whitening effect was limited. We aim to optimized microemulsion formulation which preparation and stabilized in the cosmetic industrial and enhance the penetration ability into skin simultaneous remain lightening effect. Among of commercial skin-whitening chemicals, L-ascorbic acid relative derivatives are reliable and evidence since simultaneously provided whitening, anti-oxidation potential and prevented the formation of wrinkles [1]. The ion salts derivatives have been used in commercial products, which provided whitening potential, protecting UVB induced skin damage and stimulating collagen synthesis ability [4]. Because of its hydrophilic character, AA2G has lower ability to pass through to stratum corneum and penetrate into the skin
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