Abstract
Prostate cancer remains the second leading cause of male cancer death, and there is an unmet need for biomarkers to identify patients with such aggressive disease. Piwi-inteacting RNAs (piRNAs) have been classified as transcriptional and posttranscriptional regulators in somatic cells. In this study, we discovered three piRNAs as novel prognostic markers and their association with prostate cancer biochemical recurrence was confirmed in validation data set. To obtain a better understanding of piRNA expression patterns in prostate cancer and to find gene coexpression with piRNAs, we performed weighted gene coexpression network analysis. Target genes of three piRNAs have also been predicted based on base complementarity and expression correlativity. Functional analysis revealed the relationships between target genes and prostate cancer. Our work also identified differential expression of piRNAs between Gleason stage 3 + 4 and 4 + 3 prostate cancer. Overall, this study may explain the roles and demonstrate the potential clinical utility of piRNAs in prostate cancer in a way.
Highlights
Prostate cancer is one of the most common male malignant tumors and the second leading cause of cancer death in men worldwide (Mei et al, 2013; Damborský et al, 2017)
PiRNAs Are Associated With Prostate Cancer biochemical recurrence (BCR)
We developed a custom analysis pipeline to detect expression patterns of Piwiinteacting RNAs (piRNAs) in prostate cancer patients from high-throughput sequencing data
Summary
Prostate cancer is one of the most common male malignant tumors and the second leading cause of cancer death in men worldwide (Mei et al, 2013; Damborský et al, 2017). The most common clinical diagnostic indices of prostate cancer prognosis include age, prostate-specific antigen level, tumor volume, perineural invasion, and Gleason grading (Carlsson and Roobol, 2017). Using clinical parameters alone is not sufficient for accurate prognosis (Patel and Gnanapragasam, 2016). Studies have documented that expression patterns of some ncRNAs such as lncRNA and miRNA had relationships with clinic situation of prostate cancer (Jin et al, 2011; Ru et al, 2012; Zhu et al, 2014)
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