Abstract
Effects of pentoxifylline (PTX; 20 mg/kg/day) on mortality, blood pressure, acidosis, and inflammatory mediators were studied in rats subjected to cecal ligation and puncture (CLP). PTX was intravenously given once 30 minafter CLP. Compared with controls with CLP but no drug, the PTX group showed improved survival ever 10 days of observation. PTX treatment significantly attenuated the decrease in blood pressure and increase in serum lactate concentrations in comparison to controls administrated with normal saline at 24 h after operation. Tumor necrosis factor (TNF)-a concentrations were reduced significantly by PTX in serum measured by radioimmunoassays. According to the semi-quantitative and quantitative (TaqMan) reverse-transcription polymerase chain reactions, PTX had significantly decreased TNF-a but not IL-1β gene expression in lung and liver (both p < 0.05) at 24 h postoperatively. Thus, PTX attenuated mortality, TNF-a, and lactate in this sepsis model, in association with down-regulation of TNF gene transcription. Moreover, PTX may have other various benefitical actions on sepsis. Clinical trials of PTX given early in sepsis should be considered.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
