Abstract
Transcription factors controlling E-cadherin down-regulation in ovarian cancer
Highlights
Ovarian cancer is one of the largest causes of cancer death among women (The American Cancer Society, 2017), with the highest death rate of female reproductive cancers
This review aims to discern mechanisms of E-cadherin reduction by Transcription factors (TFs) and identifies hypoxia-inducible factor 1α (HIF1α) as an upstream regulator in hypoxic conditions
Snail was found to bind more strongly to the E-cadherin promoter than Slug; it was suggested that Snail maintained epithelial–mesenchymal transition (EMT) whilst Slug induced it
Summary
Transcription factors (TFs), such as Snail, Slug and Twist, control the down-regulation of cell–cell adhesion molecule Ecadherin in ovarian cancer. This review aims to discern mechanisms of E-cadherin reduction by TFs and identifies hypoxia-inducible factor 1α (HIF1α) as an upstream regulator in hypoxic conditions. Snail was found to bind more strongly to the E-cadherin promoter than Slug; it was suggested that Snail maintained EMT whilst Slug induced it. HIF1α was shown to lie upstream of all three TFs and protein degradation or post-transcriptional regulation using miR-548c may regulate of Twist downstream. The same may be true for Twist and Slug, though some studies conflicted this These findings show promising potential of TFs and HIF1α as therapeutic targets for EMT prevention and even chemoresistance reversal
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