Abstract
Tendon formation and repair rely on specific combinations of transcription factors, growth factors, and mechanical parameters that regulate the production and spatial organization of type I collagen. EGR1 is a transcription factor is should be one of this transcription factor involved in tendon formation, healing, and repair. Using rodent animal models, we demonstrate that adult tendons of Egr1–/–mice display a deficiency in the expression of tendon genes, including Scx, Col1a1, and Col1a2, and are mechanically weaker compared with their healthy animals. Egr1 is required for the normal gene response following tendon injury in a mouse model of Achilles tendon healing. Forced Egr1 expression programmed MSCs promotes the formation of in vitro–engineered tendons and application of EGR1-producing MSCs increases the formation of tendon-like tissues in a rat model of Achilles tendon injury. This study demonstrates EGR1 involvement in adult tendon formation, healing, and repair and identifies Egr1 as a putative target in tendon repair strategies.
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