Trans-fracture approach of intra-body supporter implantation for thoracolumbar vertebral compression fractures: A technical note and 18 cases with 2-year follow-up.

Vertebral compression fractures (VCFs) are common among the elderly, causing significant morbidity, pain, and disability. This study quantitatively analyzes the vertebral height restoration via Kyphoplasty (KP) and Vertebroplasty (VP), along with the cement volume used and leakage percentage. Our meta-analysis of 14 randomized controlled trials (RCTs) compares these objective outcomes, considering cement volume and leakage in both procedures. Databases searched included Medline, PubMed, and Web of Science using MeSH keywords: 'Kyphoplasty,' 'Vertebroplasty,' 'Vertebral height restoration,' 'Bone cement volume,' and 'Vertebral compression fractures.' Fourteen RCTs were selected, focusing on outcomes such as anterior and central vertebral body height, kyphotic angle, cement volume, and leakage. Data analysis included mean values, standard deviations, ranges, Cohen's d-effect sizes, and standard errors, summarized in a forest plotQuery. The review included 1456 patients (mean age 71.11years). Follow-up ranged from 1 to 48months (mean 15months). KP showed a greater effect size in restoring anterior and central vertebral body height and kyphotic angle. Combined data from KP and VP showed increases of 3.48mm (19.14%) in anterior vertebral heights, 4.38mm in central vertebral heights, and a 2.85-degree correction in kyphotic angle. Both KP and VP effectively restore vertebral height in VCF patients. KP is superior in restoring anterior and central vertebral body height and correcting kyphotic angle. VP, particularly unilateral, shows higher central vertebral height restoration but higher cement leakage. Standardized reporting and patient-specific volumetric assessments are crucial for optimizing vertebral augmentation procedures.

Objective To compare the clinical results of dilator-kyphoplasty (DKP) and SKy-bone expander kyphoplasty (EKP) . Methods From October 2004 to May 2008, 51 patients with vertebral osteoporotic compression fracture received DKP (29 vertebras) and EKP (27 vertebras). The operation time,bleeding volume, cement injection volume were recorded during operation. The patients' visual analogue scale (VAS) and Oswestry disability index (ODI) scores were evaluated before and after operation. The cement distribution and restoration of vertebral height and Cobb angle were observed post-operation. Results There were no significant differences in operation time or bleeding volume at every vertebra between the 2 groups ( P > 0. 05). The DKP group had a significantly larger cement injection volume of (5.7 ±0. 5) mL than the EKP group [(3.6 ± 1.6) mL] ( P < 0.05). The VAS and ODI scores were decreased significantly in both groups after operation ( P < 0.05) . The vertebral height and Cobb angle were restored in both groups after operation. Nine cases ( 11 vertebras, 40. 7% ) had cement leakage in the EKP group, but one case (one vertebrae, 3.4% ) did in the DKP group. Conclusions Both DKP and EKP are efficacious and safe in the treatment of vertebral compression fractures. The vertebral anterior height, middle vertebral body height, and Cobb angle can be all restored by both procedures. DKP may be better in restoration of the vertebral anterior height, middle vertebral body height, and Cobb angle. DKP may lead to less cement leakage than EKP. Key words: Osteoporosis; Spinal fractures; Thoracic vertebrae; Lumbar vertebrae; Surgical instruments

For compression fracture, vertebral body height loss (VBHL) and kyphotic angle (KA) are two important imaging parameters for determining the prognosis and appropriate treatment. This study used previous measurement methods to assess the degree of VBHL and KA, compare and examine differences between various measurement methods, and examine the correlation between relevant measurement parameters and intravertebral cleft (IVC) in the vertebral body. The radiographic images (lateral view of the T-L spine) of 18 patients with a single-level vertebral compression fracture were reviewed. We measured 9 characteristic lengths and angles on plain radiographs, including anterior vertebral height (AVH) and AVH of the adjacent upper and lower levels, middle vertebral height (MVH) and MVH of the adjacent upper and lower levels, posterior vertebral height (PVH), and vertebral body width, and assessed 6 parameters, including vertebral compression ratio (VBCR), percentage of anterior height compression (PAHC), percentage of middle height compression (PMHC), kyphotic angle (KA), calculated kyphotic angle (CKA), and IVC. The results showed that VBCR is a simple and rapid method of VBHL assessment, but it may result in an underestimation of the degree of VBHL compared to PAHC. When PMHC < 40% or kyphotic angle > 15°, the probability of IVC occurring on the vertebral body was higher which means the higher risk of vertebral body instability. The results of this study could provide a reference for surgeons when using imaging modalities to assess the degree of vertebral body collapse.

This retrospective study investigated the impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity in 144 patients with osteoporotic vertebral compression fracture (OVCF), who received balloon kyphoplasty. Patients were divided into four groups: Group 1 had no superior endplate fracture, Group 2 had fractures on the anterior portion of the superior endplate, Group 3 had fractures on the posterior portion of the superior endplate, and Group 4 had complete superior endplate fractures. Anterior and middle vertebral body height, vertebral compression ratio, vertebral height loss rate, and kyphosis Cobb angle of each patient were measured and visual analogue scale (VAS) and Oswestry disability index (ODI) scores were recorded. The anterior vertebral height and kyphosis deformity of all groups significantly improved after the surgery, whereas substantial anterior vertebral height loss and increased Cobb angle were observed in all patients at the last follow-up. Although the vertebral height loss rate and the Cobb angle in Group 2, 3 and 4 were larger compared with Group 1 at the last follow-up, only the vertebral height loss rate in Group 4 and the increase in the Cobb angle in Group 2 and 4 were statistically different from those in Group 1. The VAS and ODI scores in all groups measured after the surgery and at the last follow-up were significantly lower compared with preoperative scores, but there was no significant difference among these groups. Balloon kyphoplasty significantly improved vertebral fracture height and kyphosis. Vertebral height loss and increased kyphotic deformity were observed in OVCF patients with endplate fractures after the surgery. Postoperative aggravation of kyphosis was observed in Group 2. Furthermore, severe vertebral height loss and increased kyphotic deformity were confirmed in Group 4 after the surgery. Our results suggested that postoperative vertebral height loss and aggravation of kyphosis may be associated with biomechanical changes in the vertebral body caused by endplate fracture. Therefore, surgery should not only restore compressed vertebral body height and correct kyphosis, but also correct the deformity of endplate to achieve an effective treatment of OVCF patients with endplate fracture.

Objective To compare the efficacy of unilateral and bilateral pedicle screw instrumentation for treatment of thoracolumbar burst fractures. Methods A retrospective case-control analysis was made on 50 patients with thoracolumbar burst fractures free from neurological deficit admitted between January 2008 and October 2013. There were 37 males and 13 females, aged from 24 to 51 years (mean, 36 years). Injuries were caused by high falls in 23 patients, traffic accidents in 18 and crashing accidents in 9. Distribution of the injured segment was T11 in 6 patients, T12 in 16, L1 in 20 and L2 in 8. Based on the surgical procedures, the patients were assigned to unilateral pedicle screw fixation group (n=35) and bilateral pedicle screw fixation group (n=15). Operation time, intraoperative blood loss and hospital length of stay were recorded. Visual analogue scale (VAS), Oswestry disability index (ODI), kyphotic angle and anterior vertebral height were evaluated before surgery, after surgery and at 1-year follow-up. Results No screw lessening, screw breakage or infection occurred at 1-year follow-up. Unilateral and lateral pedicle screw instrumentation groups revealed no significant differences in operation time [(81.4± 10.0)min vs. (83.3±13.6)min], intraoperative blood loss [(194.0±65.4)ml vs. (212.0±61.9)ml] and hospital length of stay [(10.3±1.3)d vs. (9.9±1.5)d] (P>0.05). After operation, VAS and ODI in unilateral pedicle screw instrumentation group (3 points, 73.9) showed no significance from these in lateral pedicle screw instrumentation group (2 points, 72.1) (P>0.05). VAS was within 1 point and ODI was within 20 at 1-year follow-up, showing no significant differences between the two groups (P>0.05). After operation, correction of kyphotic Cobb angle and restoration of anterior vertebral body height in unilateral pedicle screw instrumentation group (8°, 26.7%) showed no significance from these in lateral pedicle screw instrumentation group (11°, 32.1%) (P>0.05). Loss of local kyphotic Cobb angle and anterior vertebral body height in unilateral pedicle screw instrumentation group (2°, 3%) showed no significance from these in lateral pedicle screw instrumentation group (1°, 2%) at 1-year follow-up (P>0.05). Conclusion Both methods have comparable efficacy in restoring vertebral height and improving spinal kyphosis for treatment of thoracolumbar burst fractures. Key words: Spinal fractures; Fracture fixation, internal; Pedicle screws

To prospectively compare the vertebral height restoration achieved with kyphoplasty and vertebroplasty in fresh cadavers by using multi-detector row computed tomography (CT). Institutional review board approval was not required because the donors had registered in and consented to an anatomic gift program prior to their death. Thirty-seven vertebrae were harvested from four donated cadavers of elderly female individuals (mean age, 82 years; age range at death, 73-87 years). The vertebrae were dissected free of the surrounding muscles and imaged with multi-detector row CT. Compression fractures were induced, and the vertebrae were again imaged. The vertebrae were randomized to be treated with kyphoplasty (n = 19) or vertebroplasty (n = 18) and were then imaged at multi-detector row CT. The anterior, central, and posterior vertebral body heights and wedge angles were measured in the midsagittal plane of the reformatted images. The amount of cement injected was determined by weighing the vertebrae before and after treatment. The statistical significance of changes in vertebral body height, wedge angle, and weight with the two treatment techniques was evaluated with the independent t test or Mann-Whitney U test. The increase in vertebral height was greater with kyphoplasty than with vertebroplasty (5.1 mm vs 2.3 mm, respectively; P < .05). The original vertebral height was restored in 93% of vertebrae with kyphoplasty and in 82% with vertebroplasty (P < .05). There was a greater decrease in wedge angle with kyphoplasty than with vertebroplasty (3.1 degrees vs 1.6 degrees, respectively); however, this difference was not significant (P > .05). There was no significant difference in the amount of cement injected with kyphoplasty and vertebroplasty (P > .05). Kyphoplasty increased vertebral body height more than vertebroplasty in this model of acutely created fractures in fresh cadaver specimens.

BackgroundPercutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) could give rise to excellent outcomes and significant improvements in pain, analgesic requirements, function, cost, and incidence of serious complications for thoracolumbar osteoporotic vertebral compression fractures (VCFs). But some studies showed the recurrent fracture of a previously operated vertebra or adjacent vertebral fracture after PVP or PKP. The purpose of this study was to compare minimally invasive pedicle screw fixation (MIPS) and PVP with PVP to evaluate its feasibility and safety for treating acute thoracolumbar osteoporotic VCF and preventing the secondary VCF after PVP.MethodsSixty-eight patients with a mean age of 74.5 years (ranging 65 ~ 87 years), who sustained thoracic or lumbar fresh osteoporotic VCFs without neurologic deficits underwent the procedure of PVP (group 1, n = 37) or MIPS combined with PVP (group 2, n = 31). Visual analog scale pain scores (VAS) were recorded and Cobb angles, central and anterior vertebral body height were measured on the lateral radiographs before surgery and immediately, 1 month, 2 months, 3 months, 6 months, 1 year, and 2 years after surgery.ResultsThe patients were followed for an average of 27 months (ranging 24–32 months). The VAS significantly decreased after surgery in both groups (P < 0.005). The central and anterior vertebral body height significantly increased (P < 0.005), and the Cobb angle significantly decreased (P < 0.05) immediately after surgery in both groups. No significant changes in both the Cobb angle correction and the vertebral body height gains obtained were observed at the end of the follow-up period in group 2. But the Cobb angle significantly increased (P < 0.005), and the central and anterior vertebral body height significantly decreased (P < 0.005) 2 years after surgery compared with those immediately after surgery in group 1, and there were five patients with new fracture of operated vertebrae and nine cases with fracture of adjacent vertebrae.ConclusionsMIPS combined with PVP is a good choice for the treatment of acute thoracolumbar osteoporotic VCF, which can prevent secondary VCF after PVP.

Percutaneous balloon kyphoplasty (BK) is widely accepted as both a safe and effective method for the treatment of symptomatic benign vertebral compression fractures (VCFs) of the thoracic and lumbar spines. A disruption in the posterior wall of the affected vertebra is often considered to be a relative or an absolute contraindication to BK. This study was performed to determine the safety as well as the efficacy of BK for vertebral body compression fractures associated with posterior wall disruption. This was a retrospective, nonrandomized clinical cohort investigation of patients with VCF and posterior wall disruption treated with BK between 2010 and 2018. All cases were performed using a bipedicular technique. Each case was examined for cement leakage, anterior vertebral body height restoration, improvement in pain (determined by VAS) from baseline and 6-week postprocedure, and clinical sequelae from cement leakage. Ninety-eight consecutive patients with 157 VCF levels who underwent BK were evaluated. There was a significant improvement in anterior vertebral height, vertebral wedge angle, and local kyphotic angle in all cases. The mean preoperative VAS improved from 8.7 preprocedure to 2.5 postprocedure (P = .001). There were 14 (9%) cases with asymptomatic cement leakage outside of the vertebral body, and no patients experienced postprocedure neurological symptoms at the 6-week follow up. BK in the setting of posterior wall disruption was found to be a safe and highly effective treatment for patients with benign compression fractures. Posterior wall disruption should not be considered an absolute contraindication to BK.

Bone is the third most common site involved by cancer metastases, and skeleton-related events such as intractable pain due to direct osseous tumor involvement, pathologic fracture, and neurologic deficits as a consequence of nerve or spinal cord compression often affect patients' functional independence and quality of life unfavorably. The annual medical-economic burden related to bone metastases is a substantial component of the total direct medical cost estimated by the National Institutes of Health. There have been substantial recent advances in percutaneous image-guided minimally invasive musculoskeletal oncologic interventions for the management of patients with osseous metastatic disease. These advances include thermal ablation, cementation with or without osseous reinforcement with implants, osteosynthesis, thermal and chemical neurolyses, and palliative injections, which are progressively incorporated into the management paradigm for such patients. These interventions are performed in conjunction with or are supplemented by adjuvant radiation therapy, systemic therapy, surgery, or analgesic agents to achieve durable pain palliation, local tumor control, or cure, and they provide a robust armamentarium for interventional radiologists to achieve safe and effective treatment in a multidisciplinary setting. In addition, these procedures are shifting the patient management paradigm in modern-era practice. The authors detail the state of the art in minimally invasive percutaneous image-guided musculoskeletal oncologic interventions and the role of radiologists in managing patients with skeletal metastases. ©RSNA, 2021.

Restoring geometric and loading alignment of the thoracic spine with a vertebral compression fracture: effects of balloon (bone tamp) inflation and spinal extension

Many authors have reported the increase in vertebral body height after vertebroplasty. However, McKiernan et al demonstrated dynamic mobility in patients who underwent vertebroplasty and concluded that any article that claims vertebral height restoration must control for the dynamic mobility of fractured vertebrae. The purpose of this study was to compare prevertebroplasty (supine cross-table with a bolster beneath) with postvertebroplasty vertebral body height to find out whether vertebroplasty itself really increases the vertebral height. From July 2005 to July 2010, 102 consecutive patients with 132 VCFs underwent vertebroplasty at our institution. The indications for vertebroplasty were severe pain that was not responsive to medical treatment, and MR imaging-confirmed edematous lesions. Prevertebroplasty (supine cross-table with bolster beneath) lateral radiographs were compared with postvertebroplasty radiographs to evaluate the height change in vertebroplasty. Kyphotic angle and anterior vertebral body height were measured. The patients ranged in age from 62 to 90 years. There were 16 men and 86 women. The difference in the kyphotic angle between supine cross-table with bolster and postvertebroplasty was -0.49 ± 3.59° (range, -9°-16°), which was not statistically significant (P = 0.124). The difference in the anterior vertebral body height between supine cross-table with bolster and postvertebroplasty was 0.84 ± 3.01 mm (range, -7.91-8.81 mm), which was statistically significant (P = .002). The restoration of vertebral body height in vertebroplasty seems to be mostly due to the dynamic mobility of fractured vertebrae; vertebroplasty itself does not contribute much to the restoration of vertebral height.

Efficacy of bone cement volume in unilateral kyphoplasty of thoracolumbar compression fractures: A clinical comparative study.

Percutaneous pedicle screw fixation through the pedicle of fractured vertebra in the treatment of type A thoracolumbar fractures using Sextant system: an analysis of 38 cases

Objective To assess the clinical and radiographic outcome of patients who underwent percutaneous vertebroplasty (PVP) in osteoporotic compression fractures and vertebral tumor.Methods Between January 2007 and June 2012,45 patients were treated with PVP at neurosurgery department of Xuanwu hospital; it were analyzed that the clinical and radiologic outcome including cement feature.The patient's clinic outcome was assessed before operation and 24 hours,3,6,12,24,36 months after the operation using visual analogue scale (VAS) and Oswestry disability index (ODI).The anterior vertebral body height and local sagittal Cobb's angle were also measured.Results The mean follow-up period was 13.917.8 months.Postoperative VAS,ODI,the local sagittal Cobb angle decreased from 7.3 ± 1.9,32.0±3.4 and 15.0° ±2.3° to4.8 ±1.6,22.1 t2.1 and 14.0° ±1.9° respectively before and after surgery (P ＜0.05).The anterior vertebral height increased from(16.0 ± 1.8) mm to(19.0 ± 2.1) mm before and after surgery (P ＜ 0.05).There are no significant changes in VAS,ODI,anterior vertebral body height and the local sagittal Cobb's angle during 3-36 months follow-up.54％ patients maintained with decreased VAS within 5 during follow-up.Conclusion PVP is an efficient miniinvasive procedure,which can provide durable pain relief in patients with osteoporotic compression fractures and vertebral tumor. Key words: Percutaneous vertebroplasty ; Osteoporotic vertebral compression fracture ; Vertebral tumor

To investigate the clinical efficacy of percutaneous kyphoplasty (PKP) with a unilateral versus bilateral approach in the treatment of osteoporotic vertebral compression fractures (OVCFs). We retrospectively analyzed a total of 147 patients (unilateral group: 79, bilateral group: 68) with OVCFs treated with PKP at the Department of Spine Surgery, Wuhan Fourth Hospital between August 2020 and January 2022. Patients' personal information, operation time, bone cement injection volume, as well as pre- and post-operative visual analogue scale (VAS), Oswestry disability index (ODI), anterior vertebral body height and Cobb angle were recorded. All 147 patients were successfully treated with PKP and were followed up for at least 6 months. Our results showed that the operative time was significantly shorter in the unilateral group (41.60±5.64) minutes than in the bilateral group (66.53±9.40) minutes, and the volume of bone cement injected was also significantly less in the unilateral group (5.27±0.73) mL than in the bilateral group (6.87±0.93) mL (P<0.01). The VAS score, ODI index, vertebral height and Cobb angle at postoperative follow-up were significantly improved in both groups compared to the preoperative period (P<0.01); However, the difference between the two groups was not statistically significant (P>0.05). Repeat thoracic and lumbar radiographs showed cement leakage in seven cases (8.86%) in the unilateral group and five cases (7.35%) in the bilateral group, but all were asymptomatic and required no further management. During our entire follow-up period, there were five adjacent vertebral fractures in the unilateral group (6.33%) and four in the bilateral group (5.88%). There was no significant difference between the two groups in terms of improvement in VAS score, ODI index, restoration of vertebral body height, and posterior convexity deformity, but unilateral puncture had the advantage of shorter operative time and less cement injection.