Abstract
The metabotropic glutamate receptor agonist trans-(±)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) produced a slow, persistent excitation of guinea-pig olfactory cortical neurones in vitro, and the appearance of a prominent post-stimulus afterdepolarization. The corresponding slow inward tail current (I ADP) revealed under voltage clamp was insensitive to tetrodotoxin (or atropine) but was blocked by Cd 2+ or tetrabutylammonium. The I ADP properties resembled those of the slow inward tail current induced by muscarinic agonists in these neurones, suggesting a common intracellular transduction mechanism.
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