Abstract
Aims: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis. Methods: We performed an observational, multicenter, longitudinal study of 160 patients aged ≥60 years who were admitted to inward treatment of DLL. The patients were followed with 3 assessments: at inclusion (T<sub>0</sub>), at discharge from the hospital (T<sub>1</sub>), and after 1 year (T<sub>2</sub>). Growth mixture modeling was applied to identify patient classes following distinct trajectories of the Montgomery-Åsberg Depression Rating Scale (MADRS) score. Two regression models were estimated to assess clinical factors for the trajectories and for a clinical assessment of the depression course between T<sub>1</sub> and T<sub>2</sub>. Results: Two trajectory classes were identified: one with higher and one with lower MADRS scores. Not being in remission at T<sub>1</sub> and a longer hospital stay were associated with higher odds of being in the trajectory class with more severe depression. Early-onset depression (EOD) was associated with higher odds of being in a group with a poorer clinical course between T<sub>1</sub> and T<sub>2</sub>. Conclusion: EOD and not being in remission at discharge were important negative prognostic factors for DLL.
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