Abstract
TPS 622: Exposure to flame retardants and plasticizers, Johan Friso Foyer, Floor 1, August 26, 2019, 3:00 PM - 4:30 PM Bisphenol A (BPA), a well-known endocrine disrupting chemicals (EDCs), is widely used in food containers, paper, and electronics. Other bisphenols substituting to BPA are also suspected to have EDC effects. The aim of this study was to investigate the exposure sources by matching urinary bisphenols to their activities among Korea adults. Twelve adults (5 men and 7 women) were recruited in 2015. Participant were asked to collect all urine void and record the total volume of urine and the collection time for continuous seven days. A total of 401 urine samples (24-41 samples per participants) was collected. Urine samples were analysed for eight bisphenols (BPA, bisphenol S (BPS), F, Z, AF, AP, P, and B) using high-performance liquid chromatography/tandem mass spectrometry. During the period, time-activity diaries were recorded with 10-min intervals, which contained all meals, snacks and beverage, used consumer products, transportation, places and their activities. For BPA and BPS, peaks were set as levels greater than average+2 standard deviations of all samples of each participant. The activities were tracked for 6 hours prior to that time considering the half-life of BPA. The detection rate of BPA and BPS were 72 and 81%, respectively, and the others were below 15%. Average concentrations (50-95th) of BPA and BPS were 0.87 (0.48-2.84) and 0.21 (0.08-0.78) ng/ml, respectively. Urinary BPA levels in male was significantly higher than in female. A total of 20 and 21 peaks of BPA and BPS were identified, respectively, from twelve participants. BPA peaks was appeared to be associated with taking meals, beverage, snack, tooth brushing, and facial washing. BPS peaks were appeared after food consumption, tooth brushing, facial washing and wearing cosmetics. More comprehensive analysis is guaranteed to identify specific behaviours and product usage relating to bisphenols exposures.
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