Trace Elements and Sepsis: Is there a Correlation?

Abstract

International Journal of Medicine and Public Health,2018,8,4,133-139.DOI:10.5530/ijmedph.2018.4.28Published:December 2018Type:Original ArticleTrace Elements and Sepsis: Is there a Correlation?Agarwal Avinash, Kumar Anand, Gutch Manish, Consul Shuchi, Mahdi Ali Abbas, Razi Mohd Razi, Kumar Sukriti, Prakash Ved, Agarwal Vivek, and Gupta Kumar Anil Agarwal Avinash1,*, Kumar Anand2, Gutch Manish1, Consul Shuchi3, Mahdi Ali Abbas4, Razi Mohd Razi5, Kumar Sukriti6, Prakash Ved7, Agarwal Vivek8, Gupta Kumar Anil9 1Associate Professor, Department of Medicine, KGMU, Lucknow, Uttar Pradesh, INDIA. 2Senior Resident, Department of Medicine, KGMU, Lucknow, Uttar Pradesh, INDIA. 3DGO, Casualty Medical Officer, KGMU, Lucknow, Uttar Pradesh, INDIA. 4Professor and Head, Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, INDIA. 5Senior Resident, Department of Endocrinology, LLRM Medical College Meerut, Uttar Pradesh, INDIA. 6Department of Radiodiagnosis, KGMU, Lucknow, Uttar Pradesh, INDIA. 7Associate Professor, Department of Pulmonary Medicine, KGMU, Lucknow, Uttar Pradesh, INDIA. 8Associate Professor, Department of Medicine, MAYO Institute of Medical Science, Lucknow, Uttar Pradesh, INDIA. 9Associate Professor, Department of PMR, KGMU, Lucknow, Uttar Pradesh, INDIA. Abstract:Background: In critical illness blood levels of trace elements vary with the acute phase reaction. Quantitative estimation of it (Serum Selenium and Serum Zinc) can be used as prognostic markers. Aim and Objective: To evaluate the correlation between trace elements and sepsis and correlate it with various other prognostic markers with mortality in sepsis. Material and Methods: It was a prospective, observational study. One hundred and fifty patients of sepsis were enrolled after using inclusion and exclusion criteria for study. Serum Selenium and Zinc were done by Perkin-Elmer Optima ICP spectrometer. Results: One hundred and fifty patients of sepsis due to various pathological causes included in study. Mortality was 37.34%. APACHE II (33.23±5.93) and SAPS II score (67.43±10.55) was found to statisticallysignificant in predicting the mortality (p<0.001). Serum selenium in expired group of patients was found to be lower (38.26±20.82) as compared to survivors (44.34±18.99). Similarly serum zinc also appears to be lower amongdeceased (65.90±54.72) as compared to survivors (71.94±54.29) but this difference was not statistically significant. Conclusion: Our study shows that the patients with sepsis with lower level of serum selenium and serum zinc have poor outcome, but levels fails to correlate with severity of illness and death statistically. Keywords:Selenium, sepsis, Trace elements, ZincView:PDF (282.12 KB)