Abstract
Changes in intravascular pressure or stretch are known to affect vascular reactivity. However, the mechanisms that couple the changes in intravascular pressure or stretch to alterations in vascular reactivity are still not clear. In a recent review, Meininger and Davis (3) discussed possible mechanisms. The events that couple the changes in intravascular pressure or stretch to alterations in vascular reactivity may involve; (a) altered membrane properties leading to activation of ion channels, (b) modulation of biochemical cell-signaling pathways within vascular smooth muscle, (c) length-dependent changes in contractile protein function and (d) release of endothelial-derived vasoactive substances. In an intact preparation all these mechanisms are possible, and it can be difficult experimentally to assess the role of each of them separately.
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