Abstract
It is crucial to determine the safety profile of components used in food or pharma products. Acacia Nilotica exudate gum (ANG) and Soymida febrifuga exudate gum (SFG) have shown similar acacia gum properties, but their safety profile is not studied. In the present study, acute oral toxicity of ANG and SFG was investigated in female Sprague-Dawley rats for 14 days. The study aims to investigate the ANG and SFG exudate gums safety in terms of adverse reactions and mortality. Bodyweight and hematological parameters were monitored from zero-day in the interval of 2 and 7 days, respectively. This showed no significant reduction in ANG and SFG fed groups' body weight compared to the control group. Also, hematological parameters in the animal fed with ANG and SFG showed no considerable change compared to the control group. The significant increase in ALT and AST in the liver homogenate following the administration of 2000 mg/kg aqueous ANG because of the enzyme induction by the high dose of the exudate gums synthesizes the increased enzymes. The histopathological study showed no significant changes in the liver and other organ sections of animals fed with ANG and SFG compared to the control group. The LD50 of SFG and ANG were found to be more than 2000 mg/kg, and it suggested that these gum exudates were safe for food and pharmaceutical applications.
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