Abstract
Although Dolichandrone serrulata flower (DSF) aqueous extract has been shown to possess pharmacological properties, its systemic toxicity has still to be evaluated. The present study aimed to investigate the sub-chronic toxicity effect of DSF extract on biochemical parameters and histological structures of liver, kidney, testis, and epididymis plus vas deferens. Adult male rats were administered DSF at 100, 300, and 600 mg/kgBW via oral gavage for 48 consecutive days while control rats received distilled water. At the end of the experiment, blood, liver, kidney, testis, and epididymis plus vas deferens samples were collected to determine any changes to serum biochemical components including ALT, ALP, and creatinine levels and histological structures. The results revealed no significant difference in body weight and food or water consumption between control and the DSF-treated groups. It was found that DSF significantly increases the weight of epididymis plus vas deferens, while the kidney and liver showed a decrease in the high dose group (P value < 0.05). Histological changes in these vital and reproductive tissues including fibrosis were not observed after administration but ALT, ALP, and creatinine levels were significantly altered in the treated groups (P value < 0.05). These altered levels, however, were still within normal ranges. In conclusion, these findings demonstrated that D. serrulata flower extract had no sub-chronic toxicity on vital and reproductive structures but slightly altered some liver and kidney functions.
Highlights
The use of herbs for the treatment of diseases is a longstanding tradition
The relative weights of kidney and liver in DSF300 and 600 treated animals were significantly decreased when compared to the control (P < 0.05)
This study showed that Dolichandrone serrulata flower (DSF) extract did not affect liver, kidney, and reproductive organ structures after administration for 48 days
Summary
The use of herbs for the treatment of diseases is a longstanding tradition. The potential medicinal properties of plants depend on the types and amounts of their chemical compounds. The aqueous extract of DSF has been reported to have antioxidant capacity and monoterpenoids such as rengyolone and cleroindicin B (Chaimontri et al, 2021). It was noted that the continuous consumption of recent plant products over an extended period can damage vital and reproductive organs (Kiratipaiboon et al, 2012; Freitas et al, 2013; Joshi et al, 2011; Karnati et al, 2013; Lee et al, 2012). To increase our understanding of this question, the present study sought to investigate the sub-chronic toxicity of DSF extracts on vital and reproductive organs to determine the possibility of safely consuming this substance over extended periods
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Schedule a callMore From: Brazilian journal of biology = Revista brasleira de biologia
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