Abstract
Abstract Background: Bidi and gul are two locally produced nicotine-containing tobacco consumables with considerable negative health and environmental impacts, while at the same time, there is a dearth of published data on their toxicology. The LD50 (lethal dose, 50%) approach was employed in this investigation, which is the first study of its type in Bangladesh. As far as, the authors are aware. Aims and Objectives: The study determined and compared the toxicity levels of nicotine present in locally manufactured bidi and gul products. Materials and Methods: Nicotine extracts from bidi and gul were tested on Artemia salina bioassay. We found that there was significant variation in the LD50 values of the different tobacco products within their respective categories. Of the bidis tested, the most toxic brand was found to have an LD50 of 40.85 ppm, while in case of gul brands, it was 45.09 ppm which is more than double of the average nicotine content in a cigarette. Conclusion: Our results indicated that locally manufactured tobacco products (bidi and gul) have significant toxicity risk to health and environment.
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