Abstract
Toxic effects of nine representative mycotoxins to silkworm larvae have been determined by feeding trial. The 2nd and 4th instar of the larvae were fed ad libitum with artificial diet containing different concentrations of the crystalline mycotoxins for ten days. The larvae (mostly 4th instar) were highly susceptible to aflatoxin B1, G1, and ochratoxin A, and were relatively susceptible to sterigmatocystin, diacetoxyscirpenol and β-nitropropionic acid and were less to kojic acid, patulin and penicillic acid. On the eighth day after the beginning of feeding, the larvae fed on 1ppm diet of aflatoxin B1 indicated about 60% of the mortality. It was a noticeable finding that apparently reduction of number of molting of the larvae occurred at the high concentration of kojic acid administered and, in some cases of aflatoxin G1 administration, specific gross-findings which appeared in some part of the segments of the larvae were recognized as blackend and marked hyperplasic changes. Such susceptibility of larvae to aflatoxins and ochratoxin A appeared sufficient to warrant further investigation into the use of larvae as an agent for bioassay.
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