Toxic Effects of Amantadine in Patients With Renal Failure

Abstract

To the Editor: Amantadine has been used extensively in the treatment of influenza A vims respiratory illness, particularly in nursing homes. The drug is readily absorbed from the gastrointestinal tract, is not metabolized, and is excreted unchanged through the kidneys. Warning has been made repeatedly that patients with renal disease should not be given the drug or that the quantity administered should be reduced in amount. A wide variety of toxic symptoms may be manifested by patients with renal dysfunction who have been given amantadine. They may become confused, depressed, aggressive, or tense. Ataxia, dizziness, tremulousness, slurred speech, blurred vision, and convulsions have been described. Digestive disturbances, urinary retention, congestive heart failure, and orthostatic hypotension have been noted.1Ing TS Daugirdas JT Soung LS Klawans HL Mahurkar SR Hayashi JA Toxic effects of amantadine in patients with renal failure.Can Med Assoc J. 1979; 120: 695-698PubMed Google Scholar Striated muscle weakness of the type manifested by the following patient has not, to our knowledge, been described previously. It is another of the adverse reactions that may be encountered in the presence of renal failure. A 59-year-old white woman was referred for emergent treatment because of progressive muscular weakness over a period of 48 h. She was unable to walk, and swallowing and breathing became difficult. The presence of a flulike syndrome had led to the administration of 100 mg of amantadine twice a day for the prior 3 days. She had a history of essential hypertension and right pyelonephritis with a renal calculus. The blood pressure was 190/100 mm Hg, and the respiratory rate was 30 breaths per minute with accessory muscle use. A forced vital capacity of only 500 ml prompted endotracheal intubation with subsequent mechanical ventilation. Pertinent serum values were as follows: potassium, 5.4 mEq/L; phosphate, 9.8 mEq/L; and bicarbonate, 9.0 mEq/L. The blood urea nitrogen level was 111 mg/dl, and the creatinine concentration was 8.0 mg/dl. The creatine phosphokinase concentration was 55 U/L. Initial arterial blood gas values after mechanical ventilation was initiated on an FIo2 of 50 percent were as follows: Po2, 273 mm Hg; PCO2, 22 mm Hg; and pH, 7.16. The therapeutic response to halting the administration of amantadine and temporary ventilatory support was dramatic. Full muscle strength returned, and the patient was extubated within 36 h. Amantadine may release dopamine and other catecholamines from neuronal storage sites, and this activity may account for its effect in Parkinson's disease. The drug also enhances the effects of anticholinergic drugs, such as atropine and scopolamine.2Hahn AB Barkin RL Oestreich SJK Pharmacology in nursing. 15th ed. CV Mosby, St Louis1982: 290-291Google Scholar These modes of behavior, however, would not account for the symptoms seen in this patient. Amantadine has another action, which has been exquisitely demonstrated by Tsai et al.3Tsai MC Mansour NA Elderfrawi AT Elderfrawi ME Edson X Mechanism of action of amantadine on neuromuscular transmission.Mol Pharmacol. 1978; 50: 787-803Google Scholar The activity was centered on acetylcholine receptor-mediated postsynaptic conductance. They stressed that amantadine did not react with the recognition site of acetylcholine, but rather with the ionic channel of the receptor, and that it blocked neurotransmission in a voltage-dependent manner. The precaution that amantadine should not be given to patients with renal disease was not observed in this case, as the prescribing physician was unaware of the patient's renal insufficiency. The inability to excrete the drug produced toxic levels with the production of serious muscular paresis and respiratory difficulty. Toxic effects of amantadine in patients with renal failureCHESTVol. 105Issue 5PreviewTo the Editor: Full-Text PDF