Abstract
Towards the Resurrection of the Delta-Opioid Receptor Antagonists in Haemodynamic Shock Management?
Highlights
We refer to the papers by Liu et al [1] and by Duranteau and Le Manach [2] appeared on Anesthesiology, dealing with the suitable employment of the δ-opioid receptor antagonist ICI 174864 (N,N, diallyl-tyr-aibaib-phe-leu-OH) in experimental haemorrhagic shock and of δ-opioid receptor antagonists for “buying time” in haemorrhagic shock patients, respectively
We showed that the selective blockade of cardiovascular δ-opioid receptors by ICI 174864 or naltrindole improved haemodynamics, prevented shock irreversibility and reduced plasma nitric oxide (NO) levels; similar effects were obtained by selective inhibition of inducible NO synthase by AMT ( ± 2-amino-5,6-dihydro6-methyl-4H-1,3-thiazine, HCl) but not by blocking opioid receptors other than the δ ones or by using drugs like fenoprofen and hydrocortisone [3]
Considering that splanchnic artery hypoperfusion had been suggested to play a significant role for the development of haemodynamic shock irreversibility, our experimental model was just assessed to establish the critical levels at which SMA hypoperfusion (SMAH) by itself could induce haemodynamic shock
Summary
We refer to the papers by Liu et al [1] and by Duranteau and Le Manach [2] appeared on Anesthesiology, dealing with the suitable employment of the δ-opioid receptor antagonist ICI 174864 (N,N, diallyl-tyr-aibaib-phe-leu-OH) in experimental haemorrhagic shock and of δ-opioid receptor antagonists for “buying time” in haemorrhagic shock patients, respectively. Towards the Resurrection of the Delta-Opioid Receptor Antagonists in Haemodynamic Shock Management?
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