Abstract
in vitro毒性試験は，一般的に“単回”ばく露により実施される．一方，労働者の化学物質ばく露と関連した遅延性疾患 （例: がん） の背景には，“慢性的”ばく露が関連すると考えられる．そのため，反復ばく露による毒性評価は，作業現場のばく露形式に近い毒性情報として，労働衛生学的に有用となり得る．しかし反復ばく露によるin vitro毒性試験の実施例は限定的であり，単回ばく露との差異に関する情報は殆ど存在しない．
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