Abstract
Vancomycin hydrochloride release from coated poly( dl-lactide) cylinders was examined. The release profiles of vancomycin hydrochloride, gentamicin sulfate, and cefazolin sodium, were fitted by Fick's diffusion equation for a simple slab. Although the equation over-predicted the early release rates from cylinders with low drug loading, it served as a reasonably satisfactory tool to describe the release profiles. The effective diffusion coefficient, D eff, was critically dependent on the drug loading, drug particle size, and device length. By estimating D eff based on values obtained from vancomycin, gentamicin, and cefazolin, the release profile, from the coated cylinder, for a highly water soluble antibiotic with known particle size, can be predicted and used for device design calculations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
