Abstract
Background Atrial fibrosis identification by late gadolinium enhancement (LGE) CMR is important as a precursor to atrial fibrillation, and may impact the outcome of catheter ablation. However, the LGE enhancement in the thin atrial wall is difficult to accurately and reproducibly detect. We sought to improve identification of fibrosis through T1-mapping, generating an index of the extracellular volume fraction (ECV). In order to achieve high spatial resolution mapping for a narrow range of relevant T1-values (250-500ms) in a feasible scan time, we applied fit-free T1-mapping with only 3 TI values (3-pt). Preliminary data measuring the ECV of normal myocardium and the aortic valves—a thin fibrotic structure– are presented.
Highlights
Atrial fibrosis identification by late gadolinium enhancement (LGE) CMR is important as a precursor to atrial fibrillation, and may impact the outcome of catheter ablation
Phantoms with a range of T1s (200650ms), with T1 measured by spin echo inversion recovery (IR), were imaged to compare the performance of our standard T1-mapping with 6 TIs (100 to 500ms, ∞) estimated using least-squares fitting, to the fit-free 3-pt method
T1-maps of the left atrium were obtained in a study of Yorkshire swine (n = 5) one to two weeks after myocardial infarction, ~30 minutes post injection of 0.2mmol/kg gadobutrol
Summary
Atrial fibrosis identification by late gadolinium enhancement (LGE) CMR is important as a precursor to atrial fibrillation, and may impact the outcome of catheter ablation. The LGE enhancement in the thin atrial wall is difficult to accurately and reproducibly detect. We sought to improve identification of fibrosis through T1-mapping, generating an index of the extracellular volume fraction (ECV). In order to achieve high spatial resolution mapping for a narrow range of relevant T1-values (250-500ms) in a feasible scan time, we applied fit-free T1-mapping with only 3 TI values (3-pt). Preliminary data measuring the ECV of normal myocardium and the aortic valves—a thin fibrotic structure– are presented
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