Abstract
Progress in immunosuppressive therapy has reduced the incidence of acute graft rejection and gives excellent short-term results in clinical organ transplantation. There remains, however, the problem of chronic graft-rejection and, because immunosuppressive drugs lack specificity, long-term therapy is associated with severe side-effects such as a high incidence of cancer and opportunistic infections. The obvious solution for these problems is the induction of donor-specific transplantation tolerance.
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