Abstract
AbstractAn asymmetric aldol reaction using Oppolzer's sultam has provided a practical and efficient synthetic route (15 steps, overall yield ca. 24 %) to 12 compounds of the Antimycin A family and deisovalerylblastmycin, which were obtained in pure form on a 60–300 mg scale. In the syntheses, the nine‐membered dilactone ring was constructed successfully by lactonization of a 2‐pyridinethiol ester bearing a TIPS group on the 8‐OH by using the (CuOTf)2·PhH complex.
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