Total synthesis of murraol, (E)-Suberenol and toward the collective total synthesis of exotines A, cnidimonins A-Cetc

Abstract

Simple and efficient syntheses of murraol and (E)-suberenol were accomplished in just three simple steps from cheap and readily available 4-methoxysalicylaldehyde implementing a protecting-group-free and redox-neutral strategy. In the adopted approach, a practical regioselective bromination reaction and a high yield Mizoroki-Heck reaction from previously inactive bromocoumarin were conducted. This newly established high yield, gram scale synthetic method was further furnished the formal synthesis of a series of novel dimeric natural products.