Abstract
Dysidavarone A is a sesquiterpene isolated from the South China Sea sponge Dysidea avara and was reported that it showed significant anticancer activities. Because the compound has unique ‘dysidavarane’ carbon skeleton and potent biological activity, a seven-step stereoselective synthesis of dysidavarone A was developed. The key steps of the synthesis involved stereoselective reductive-alkylation, intramolecular α-arylation and double bond migration reaction. The anti-proliferation activities of Dysidavarone A against human kidney carcinoma cell lines 786-O and human prostate cancer cell lines PC-3 were also assessed.
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