Abstract
The objective of this study is to investigate total phenolic content, antioxidant and antityrosinase activities of G.dulcis root extract and fractions (A-J). It found that the total phenolic content of the crude extract was 338.42 ± 6.08 mg GAE/g extract. The extract showed good activity against DPPH (IC50 71.07 ± 0.02 μg/ml), ABTS (IC50 28.08 ± 0.01 μg/ml) and good ferric reducing antioxidant power (235.40 ± 3.44 mg AAE/g extract). It also showed inhibitory activity toward tyrosinase enzyme (IC50 354.15 ± 0.13 μg/ml). Fractions E and I showed better activity than the extract and other fractions in all tested. 12b-hydroxy-des-D-garcigerin A and globuxanthone are major components from fraction E and symphoxanthone was obtained from fraction I. The result indicated that fraction from G.dulcis root extract is a natural antioxidant and antityrosinase source with potential for use as active ingredients in cosmetics.
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