Abstract
Introduction: Pancreatic adenocarcinoma (PAC) is one of the leading causes of cancer deaths with rising prevalence in recent years. Surgical resection is the only potentially curative treatment for PAC. Pancreatic leak is a major complication of pancreaticoduodenectomy (PD), while total pancreatectomy (TP) can result in brittle insulin-dependent diabetes mellitus and cachexia-like syndrome with previously high mortality rates that rendered TP impractical and largely abandoned. However, recent advancements in the treatment of DM, drop-in mortality rate, and reduced pancreatic leak risk has led the surgical community to retrospectively review TP cases in comparison to PD.
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