Abstract
During the postoperative period following cardiopulmonary bypass (CPB), oxygen free radicals are generated by the whole body inflammatory response. Intracellular and extracellular compartments possess defense mechanisms against oxygen free radical damage referred namely status. The purpose of this study was to investigate the early postoperative changes of total antioxidant capacity of HDL in patients before and after coronary surgery. Eleven patients undergoing coronary artery bypass surgery participated in this study and their HDL was obtained from both preoperative and 2-day postoperative plasma by sequential ultracentrifugation. Total antioxidant capacity of HDL was measured by using radical cation decolorization (TEAC) assay. Using students t-test, total antioxidant status of HDL from most patients remained unchanged for at 2 days after operation (p>0.05). Further studies are required in more patients and at prolonged interval times.
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