Abstract
Torin 1, is an ATP-competitive kinase inhibitor targeting rapamycin (TOR) which inhibits the signaling of TOR and S6K kinase in mammals and plants. During kinetics growth of tobacco cultures suspended in NT-1, Torin 1 inhibits the early growth and later enhanced the cellular proliferation during exponential growth by means of an increased expression of E2F1 and cyclin B.
Highlights
The target of rapamycin (TOR) is a conserved eukaryotic phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) that regulates growth and metabolism in response to environment [1,2,3]
Arabidopsis sensitivity to high concentrations of rapamycin (100-1000 nM) has been reported; the authors suggest that the variable effects on insensitivity to rapamycin in various biological systems could be linked to variations in the amount of FKBP12 protein, which could explain the controversy around the resistance of certain plants to this inhibitor [13]
The present study aims to study the effect of Torin 1, one of inhibitors of second generation of TOR, on plant growth in a relatively simpler system than plants such as NT-1 suspension cultures of tobacco cells
Summary
The target of rapamycin (TOR) is a conserved eukaryotic phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) that regulates growth and metabolism in response to environment [1,2,3]. TOR level correlates with plant size indicating its central role in plant development [3]. This kinase regulates processes like translation, ribosome biogenesis, actin dynamics, production of reactive oxygen species (ROS) and autophagy [8]. While rapamycin resistance has been reported in some higher plant, there are other plants, e.g., corn and green algae such as Chlamydomonas reinhardtii [11,12], which are sensitive to its effect. Several reports concerning at use of Torin 1 in plants, showed a strongly inhibit growth of a large variety of plants like Arabidopsis, potato, tomato, rice, Lotus, millet and Nicotiana and proliferation in both green algae and DOI:10.32604/phyton.2019.05036 www.techscience.com
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