Abstract
See related article, page 405 Topiramate was approved in the United States in 1996 for the treatment of generalized tonic-clonic and partial seizures. An indication for migraine prophylaxis was added in 2004. The drug has been used on an off-label basis for eating, sleep, and psychiatric disorders. Recently, a combination of phentermine and topiramate was approved for chronic weight management in overweight or obese adults with a weight-related disorder. Margulis and colleagues, noting that some of these conditions are particularly prevalent among women of child-bearing age, looked for a link between topiramate use in pregnancy and cleft lip with or without cleft palate in offspring.
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