Abstract
AbstractThe deposition of a-interferon into living skin strata of hairless mouse following topical in vivo application of a glyceryl dilaurate: POE-10: cholesterol liposomal formulation was much higher than from a glyceryl distearate: POE-10: cholesterol liposomal formulation or from an aqueous solution. The kinetics and extent of drug deposition from the liposomal formulations appear to correspond to the extent of release of bilayer lipid components following topical application and subsequent action of the lipid components as skin permeation enhancers.
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