Abstract
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a well-known adverse effect of chemotherapy treatment. Despite its prevalence, prevention and treatment of CIPN remain challenging. CASE REPORT: In this case series, we present the use of topical 0.075% capsaicin as a preventative measure for CIPN in patients with newly-diagnosed stage II breast cancer undergoing chemotherapy. Patients were instructed to use capsaicin cream 3 times daily on hands and feet throughout the course of chemotherapy and for an additional month after chemotherapy concluded. CONCLUSIONS: None of the 5 patients had any symptoms suggestive of CIPN after being followed for 12 months. These findings support further investigation of low-dose capsaicin as a prophylactic measure to prevent CIPN. KEY WORDS: Chemotherapeutic-induced peripheral neuropathy, topical capsaicin, preventative, neuropathy, cancer pain
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