Abstract
We observed that oleuropein, the main constituent of the leaves and unprocessed olive drupes of Olea europaea, protected mice from high-fat diet-induced adiposity by up-regulation of genes involved in Wnt10b-mediated signaling in adipose tissue. The activation of Wnt/β-catenin pathway is also well established to positively regulate the anagen phase of hair growth cycle in mice skin.Methodology and Principal FindingsOleuropein promoted cultured human follicle dermal papilla cell proliferation and induced LEF1 and Cyc-D1 mRNA expression and β-catenin protein expression in dermal papilla cells. Nuclear accumulation of β-catenin in dermal papilla cells was observed after oleuropein treatment. Topical application of oleuropein (0.4 mg/mouse/day) to C57BL/6N mice accelerated the hair-growth induction and increased the size of hair follicles in telogenic mouse skin. The oleuropein-treated mouse skin showed substantial upregulation of Wnt10b, FZDR1, LRP5, LEF1, Cyc-D1, IGF-1, KGF, HGF, and VEGF mRNA expression and β-catenin protein expression.Conclusions and SignificanceThese results demonstrate that topical oleuroepin administration induced anagenic hair growth in telogenic C57BL/6N mouse skin. The hair-growth promoting effect of oleuropein in mice appeared to be associated with the stimulation of the Wnt10b/β-catenin signaling pathway and the upregulation of IGF-1, KGF, HGF, and VEGF gene expression in mouse skin tissue.
Highlights
The hair follicle, a specific mini-organ appendage of the skin, is composed of epidermal and dermal compartments, and their interaction plays an important role in the growth of the hair follicle [1,2]
These results demonstrate that topical oleuroepin administration induced anagenic hair growth in telogenic C57BL/6N mouse skin
The hair-growth promoting effect of oleuropein in mice appeared to be associated with the stimulation of the Wnt10b/β-catenin signaling pathway and the upregulation of insulin-like growth factor-1 (IGF-1), Keratocyte growth factor (KGF), Hepatocyte growth factor (HGF), and Vascular endothelial growth factor (VEGF) gene expression in mouse skin tissue
Summary
The hair follicle, a specific mini-organ appendage of the skin, is composed of epidermal (epithelial) and dermal (mesenchymal) compartments, and their interaction plays an important role in the growth of the hair follicle [1,2]. Hair follicle formation largely takes place during fetal and perinatal skin development [3]. Mature and actively growing hair follicles eventually become anchored in the subcutis and are periodically regenerated by spontaneously.
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