Top 2020 studies relevant to primary care

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<h3>Objective</h3> To summarize high-quality studies for 10 topics from 2020 that have strong relevance to primary care practice. <h3>Selecting the evidence</h3> Study selection involved routine literature surveillance by a group of primary health care professionals. This included screening abstracts of high-impact journals and EvidenceAlerts, as well as searching the American College of Physicians Journal Club. <h3>Main message</h3> Topics of the 2020 articles most likely to affect primary care practice included whether antibiotic prophylaxis reduces maternal infections following operative vaginal birth; which second-line agent after metformin reduces cardiovascular outcomes for patients with diabetes; whether gabapentin is effective for alcohol use disorder; whether compression stockings prevent recurrent cellulitis; guideline recommendations for management of dyslipidemia to reduce cardiovascular risk; whether intermittent fasting is superior to consistent mealtimes for weight loss; whether vitamin C added to iron supplementation increases hemoglobin more than iron alone; whether antacid-lidocaine combinations are superior to antacid alone for epigastric pain; whether dapagliflozin improves renal and cardiovascular outcomes in chronic kidney disease; and whether empagliflozin improves cardiovascular outcomes in patients with heart failure. Five “runner-up” studies are also briefly reviewed. <h3>Conclusion</h3> Research from 2020 produced several high-quality studies in diabetes and cardiovascular disease, but also included a variety of other conditions relevant to primary care such as vaginal operative births, alcohol use disorder, weight loss, and chronic leg edema.