Abstract
The current concept of “pressure-tension” tooth movement is based upon reductionist explanations of parsed physiological processes that do not provide a cohesive understanding of clinically relevant tooth movement. The biology underlying accelerated orthodontic techniques have refocused attention on disruptions of tensional integrity of microenvironments, resulting in epigenetic changes in cell products, and the intentional spatio-temporal adaptations of tissues to build strength to overcome tissue strain, all for the sake of re-establishing homeostasis. Differentiating how interstitial bone fluid pressure and flow is affected by the various tissue microporosities in regulating bone modeling and remodeling processes, will lead to a better understanding of tooth movement mechanobiology.
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