Abstract
目的 探讨肝移植预输注地塞米松体内诱导凋亡的供体脾细胞诱导受体肝移植免疫耐受可能性.方法实验分5组,对照组,单纯供体地塞米松处理组,单纯输供者脾细胞组,地塞米松诱导供者凋亡脾细胞输注组,第三品系组.每组均做Wistar至SD的肝移植,每组各10只Wistar、SD大鼠.用地塞米松3 mg/(kg·d)处理Wistar大鼠3 d后,第4天取供体的脾细胞输注受体,第10天行大鼠肝移植.观察术后第7天肝功能(ALT、Tbil)的变化、病理改变和受体生存期.结果肝移植预输注凋亡细胞组的ALT、Tbil较其它各组显著低(P<0.05);生存期明显长(P<0.05),病理改变较轻.结论肝移植预输注地塞米松体内诱导供体凋亡的脾细胞能诱导受体大鼠对移植肝的免疫耐受。
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