To study the correlation of peripheral blood F-box and WD repeat domain-containing domain protein7 and myeloid cell leukemia-1 expression levels with the prognosis of Icotinib administration in elderly patients with advanced non-small-cell lung cancer

Abstract

Objective To study the correlation of the prognosis of Icotinib administration with the expression levels of F-box and WD repeat domain-containing 7(FBW7) and myeloid cell leukemia-1(MCL-1) in peripheral blood in elderly patients with advanced non-small-cell lung cancer. Methods A total of 76 patients aged 60 years or over diagnosed with non-small-cell lung cancer(NSCLC)with EGFR-sensitive mutations and under Icotinib treatment were enrolled in this study.FBW7 and MCL-1 mRNA expression levels in peripheral blood were detected by real-time quantitative PCR(RT-QPCR). The correlation of FBW7 and MCL-1 expression levels with clinical and histological parameters, overall survival(OS), and progression-free-survival(PFS)was analyzed. Results The FBW7 expression level and the MCL-1 expression level were negative correlated(r=-0.37, P<0.001). High FBW7 expression levels and low MCL-1 expression levels in peripheral blood were associated with improved therapeutic efficacy of Icotinib (P<0.001) and extended OS and PFS.Cox regression analysis showed that the expression levels of FBW7 and MCL-1 in peripheral blood were independent influencing factors for OS and PFS. Conclusions Patients with high FBW7 expression levels and low MCl-1 expression levels are more likely to benefit from Icotinib treatment.Expression levels for either factor can be used as a predictive indicator for the effectiveness of Icotinib and provide guidance for its clinical use. Key words: Carcinoma, non-small-cell lung; Ubiquitin-protein ligases; Myeloid cell leukemia-1; Icotinib