Abstract
The cell bodies of Purkinje Cells are extremely rich in Endoplasmic Reticulum (ER) stacks associated with a semi-crystalline array of inositol- 1,4,5-trisphosphate receptor (IP3 receptor) (Katayama et al: EMBO Journal vol.15 no.18 pp.4844-4851, 1996). Calcium release from IP3 receptor is the major component of calcium movement in the cell bodies. The ER stacks are closely associated with the mitochondrial surfaces and we have explored their relative positions.Taking advantage Katayama's work, we have considered the question of whether the IP3 receptors are located on the mitochondrial-facing ER surface.We examined the thin section ultrastructure of rat cerebellar Purkinje cells fixed by perfusing via the carotid artery.The ER stacks show clear “periodically arranged small densities”, presumably IP3 receptors.
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