TO EVALUATE CARDIAC BIOMARKERS AND ECG CHANGES IN ASSESSING CARDIAC DYSFUNCTION IN CHILDREN WITH ACUTE SEVERE BRONCHIAL ASTHMA

Abstract

Introduction:Asthma is a chronic inammatory disease of the airways, characterized by recurrent episodes of airow obstruction resulting from edema, bronchospasm, and increased mucus production. There are an estimated 300 million people who have asthma worldwide, with a signicant geographic variation of prevalence, severity, and mortality. The exact etiology of asthma remains unclear and appears to be multifactorial. Both genetic and environmental factors seem to contribute. Aim and Objective: To evaluate role of cardiac biomarkers and ECG changes in assessing the cardiac dysfunction in children with acute severe bronchial asthma. Material and Methods: This was Prospective, observational, Hospital based study at department of pediatric medicine, SPINPH (JK Lone hospital), SMS Medical College, Jaipur, Rajasthan. The study includes 51 patients admitted during study period of 18 months. Sample size was calculated of 95% condence level, α error of 0.05 expecting 15% abnormal CK-MB levels as one of the biomarker in children with acute severe bronchial asthma. Result: The study included Sample size of 51 Patients in each group. In our study, mean age of study participants was 8.8±2.5 years. Out of the 51 participants, 37 were in age of 5-10 years and 14 in age above 10 years. Male participants were 32 and female were 19. Mean FEV1 of study participants was 77.7±5.7%. Conclusion: Our study concluded that at the time of admission, children with acute severe bronchial asthma exhibited abnormal CPK-MB in 21.6%, abnormal trop-I in 58.8%, and abnormal BNPin 11.6%. The most common ECG nding in these patients was sinus tachycardia