Abstract
Background: The dermatophytoses are caused by a group of fungi known as ringworm or Tinea. These are from genera Microsporum, Trichophyton and Epidermophyton. Amongst Five to six species which are prevalent globally, Trichophyton rubrum happens to be the commonest.
 Methods: A hospital based comparative prospective study included 600 patients of dermatophytoses having Tinea cruris and Tinea corporis attending the outpatient department of Dermatology, Venereology and Leprosy in PBM hospital Bikaner. Patients randomly divided into 3 groups - Group A received Tablet Fluconazole 150 mg per week plus Tablet Griseofulvin 10mg per kg bodyweight daily in two divided doses. Group B received Tablet Fluconazole 150 mg per week. Group C received Tablet Griseofulvin 10mg per kg body weight in two divided doses daily. Treatment to all groups was given for a period of 4 weeks. The data were analyzed on EPI-Info-6 Software. 
 Results: There were no statistically significant difference noted among three groups at 1st, 2nd & 3rd weeks and statistically significant difference in three groups was observed at 4th & 8th weeks follow-up.
 Conclusion: The combination of Fluconazole and Griseofulvin is a bettar treatment option to treat tinea cruris and corporis as compared to mono therapy with Fluconazole or Griseofulvin.
 Keywors: Fluconazole ,Griseofulvin, Mono Therapy, Dual therapy, Tinea Cruris and Tinea Corporis.
Highlights
Background: The dermatophytoses are caused by a group of fungi known as ringworm or Tinea
These are from genera Microsporum, Trichophyton and Epidermophyton
Patients randomly divided into 3 groups - Group A received Tablet Fluconazole 150 mg per week plus Tablet Griseofulvin 10mg per kg bodyweight daily in two divided doses
Summary
The dermatophytoses are caused by a group of fungi known as ringworm or tinea. These are from genera Microsporum, Trichophyton and Epidermophyton.[1] Amongst Five to six species which are prevalent globally, Trichophyton rubrum happens to be the commonest[2]. The choice of treatment is determined by the site and extent of lesions, the fungal species involved and the efficacy, safety profile and pharmacokinetics of the available antifungal agents.[7]. In the present study we have compared the different drug regimen for trement of tinea corporis and cruris and advantage of using combination treatment of fluconazole and giseofulvin for treatment of tinea cruris/corporis
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