Abstract
Method: Study including LPA /AFB CULTURE proven cases of MDR TB. Data will be collected from the patient attending the OPD & IPD in the Dept. of Respiratory Medicine.
 Result: Out of 200 patients 71% were of male its shows that MDR T.B. more prevalent among males and female 29%. Out of 200 patients most of the patients come under 10-15 Kg/m2 BMI, so its shows that 64.5% patients comes it and disease more prevalent among under nutrition. Out of 200 patients, the present study shows that gastrointestinal side effects are the most common 42%. 09 patients have renal toxicity and 08 patients have Arthalgia and 06 patients have cutaneous reactions and 11 patients developed hepatitis and 07 patients have some psychiatric illness and 07 patients developed hearing defect.
 Conclusion: The present study shows that gastrointestinal side effects are the most common 42%. 09 patients have renal toxicity and 08 patients have Arthalgia and 06 patients have cutaneous reactions and 11 patients developed hepatitis and 07 patients have some psychiatric illness and 07 patients developed hearing defect. Overall, these findings emphasize the importance of continuing the systematic surveillance of M. tuberculosis isolates to monitor the trends of drug resistance in different patient categories.
 Keywords: Adverse, Second line & MDR TB.
Highlights
The emergence of resistance to drugs used to treat tuberculosis (TB), and multidrug-resistant TB (MDR-TB), has become a significant public health problem in a number of countries and an obstacle to effective TB control
Out of 200 patients, the present study shows that gastrointestinal side effects are the most common 42%. 09 patients have renal toxicity and 08 patients have Arthalgia and 06 patients have cutaneous reactions and 11 patients developed hepatitis and 07 patients have some psychiatric illness and 07 patients developed hearing defect
The present study shows that gastrointestinal side effects are the most common 42%. 09 patients have renal toxicity and 08 patients have Arthalgia and 06 patients have cutaneous reactions and 11 patients developed hepatitis and 07 patients have some psychiatric illness and 07 patients developed hearing defect
Summary
The emergence of resistance to drugs used to treat tuberculosis (TB), and multidrug-resistant TB (MDR-TB), has become a significant public health problem in a number of countries and an obstacle to effective TB control. The term “Programmatic Management of Drug Resistant TB” (PMDT) (erstwhile DOTS Plus), refers to program based MDR-TB diagnosis, management and treatment These guidelines promote full integration of basic TB control and PMDT activities under the RNTCP, so that patients with TB are evaluated for drug-resistance and placed on the appropriate treatment regimen and properly managed from the outset of treatment, or as early as possible[3]. The guideline introduces new standards for registering, monitoring and reporting outcomes of multidrug-resistant TB cases This uniform information management system will allow systematic, consistent data collection and analysis which will facilitate appropriate supervision and monitoring of the PMDT activities and will play an important role in shaping future policies and recommendations[4]
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